• Addresses the root cause of the issue
  Direct effect on the main cystitis cause – E.coli.
• Quick and long-lasting effect
  Proven: Reduces cystitis relapse ⁽¹⁾.
• Multipurpose and safe
  Can be used as an independent product and as a part of therapy.
• Convenient format
  One sachet to make a drink once a day.

Delicate problems
A solution, not a disguise!
Global medical communities confirm cystitis as the leading urological issue among women. 30–50% of women experience it at least once, while urinary system inflammation:
– impairs the regular way of life;
– is often the reason for discomfort in sexual life;
– is a manifestation of hidden gynecological problems.

Preventing inflammations and proactively safeguarding the urogenital system is the key to ensuring your comfort and a fulfilling life. «D-Mannose & Cranberry Extract» by Siberian Wellness is a natural product that addresses the root cause of cystitis (E. coli) and has proven effectiveness⁽¹⁾!

Modern urinary protection products with proven efficiency

• D-mannose
  D-mannose is a glucose isomer that is found in both plant and animal polysaccharides. It binds to E. coli fimbriae, preventing their attachment to the bladder walls. As a result, these bacteria are then flushed out of the body with urine without causing any harm.
  The most common bacterial cause of cystitis, accounting for 95% of cases, is uropathogenic Escherichia coli. These bacteria possess numerous filaments known as fimbriae, which they use to attach to the cells in the bladder. After attaching, the bacteria take nutritive substances from the cells and release toxins causing cell damage. This is how the bladder wall inflammation begins, i.e. cystitis. D-mannose binds bacterial fimbriae preventing their attachment to the bladder walls. These «bound» bacteria are removed from the body through urination without causing any damage or inflammation to the mucosa.
• Plant extracts
  A combination of herbal uroseptic extracts (cranberry, hibiscus, bearberries and horseradish) complements, enhances, and extends the effectiveness of the primary component, aiding in the management of inflammation and discomfort.
     • Cranberry extract
  A source of proanthocyanidins, which are polyphenolic compounds known for their exceptionally strong antioxidant properties and their powerful effects on all cells in the body. They reduce the inflammatory mediators release and thus an anti-inflammatory effect is provided.
     • Hibiscus extract
  Contains bioflavonoids with an antimicrobial activity (they slow down metabolism in microbial cells and prevent them from releasing toxins).
     • Bearberry extract
  Contains arbutin which has antibacterial properties.
     • Horseradish extract
  Rich in essential oils that provide the perfect bactericidal effect.

When and who should take this product?
As a preventive measure against inflammatory diseases of the urinary system:
• For women and men.
• Emergency and scheduled medical care.
• In case of exacerbation of a chronic condition or during an acute relapse as part of a comprehensive treatment approach.

Each sachet contains::
   • 1500 mg of D-mannose
Quicker discomfort relief from frequent urination.
   • 4 botanical extracts
Reliable protection against inflammations.

Cystitis prevention after sex
Episodes of acute cystitis after sexual intimacy can occur at any age. The reason is anatomy. The female urogenital system's proximity to the anus increases the risk of coliform bacteria reaching the bladder and subsequently causing inflammation.
To avoid unpleasant consequences, a single intake of «D-Mannose & Cranberry Extract» after intercourse is possible for cystitis prevention.

¹ Prevention of urinary tract infections without the use of antibiotics.
Néha Sihra, Anna Goodman, Rhana Zakri, Arun Sahai, Sachin Malde Nat Rev Urol. 2018 Dec https://pubmed.ncbi.nlm.nih.gov/30361493/